[The anti-ischemic properties of crown ether derivatives].

Abstract

Experiments on open-chest anaesthetized cats were made to test derivatives of crown ethers, such as benzylase-15-crown-5 and dibenzylase-15-crown-5 for their effects on myocardial ischemia and the functional status of a myocardial ischemic focus in temporary coronary occlusion during coronary spasm induced by dihydroergotamine and during coronary microthrombosis caused by ADP. When intravenously administered in doses of 0.5-15 mg/kg, the tested agents were found to enhance myocardial tolerance to ischemia, depressed ST segment in ischemia induced by coronary occlusion and administration of ATP, and prevented ST-segment depression during coronary spasm.

• Authors: K G Gurbanov, A A Paperno, N G Luk'ianenko, S S Basok
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1993 Sep-Oct Vol. 56 Issue 5 Pg. 18-21 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Protivoishemicheskie svoĭstva proizvodnykh kraun-éfirov.
• PMID: 8312801 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Crown Ethers
• Ethers, Cyclic
• benzylaza-15-crown-5

Topics

• Animals
• Cats
• Crown Ethers
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Drug Tolerance
• Electrocardiography (drug effects)
• Ethers, Cyclic (therapeutic use, toxicity)
• Female
• Lethal Dose 50
• Male
• Mice
• Myocardial Ischemia (drug therapy, physiopathology)