Abstract |
The aim of this study was to investigate the ability of Triclosan dentifrices to delay the development of gingivitis during a 21-day period without toothbrushing. Test pastes contained 0.3 per cent Triclosan; seven also contained 0.75 per cent zinc citrate; one other contained 2 per cent Gantrez. Plaque and gingivitis increased significantly (p < 0.001) between day 0 and day 21 in the control group. there was no evidence to reject the assumption of similar efficacy across the seven Triclosan/ zinc citrate variants. For the combined Triclosan/ zinc citrate groups, statistically significant reductions in plaque formation and in gingivitis relative to the control were recorded. Reductions in plaque and gingival bleeding compared to control for the Triclosan/ Gantrez group were not statistically significant, although reductions in gingival indices were. The greater reduction in the Gingival Index of the Triclosan/ zinc citrate group was also statistically significantly different from that of the Triclosan/ Gantrez group, suggesting that a dentifrice containing the former would have a greater antigingivitis potential than a dentifrice containing the latter.
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Authors | C A Saxton, E Huntington, D Cummins |
Journal | International dental journal
(Int Dent J)
Vol. 43
Issue 4 Suppl 1
Pg. 423-9
(Aug 1993)
ISSN: 0020-6539 [Print] England |
PMID | 8282425
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Citrates
- Dentifrices
- Drug Combinations
- Maleates
- Polyvinyls
- polyvinylmethoxyethylene-maleic anhydride copolymer
- Citric Acid
- Triclosan
- Zinc
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Topics |
- Adult
- Citrates
(administration & dosage, therapeutic use)
- Citric Acid
- Dental Plaque
(prevention & control)
- Dentifrices
- Drug Combinations
- Gingival Hemorrhage
(prevention & control)
- Gingivitis
(prevention & control)
- Humans
- Maleates
(administration & dosage, therapeutic use)
- Periodontal Index
- Polyvinyls
(administration & dosage, therapeutic use)
- Triclosan
(administration & dosage, therapeutic use)
- Zinc
(administration & dosage, therapeutic use)
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