Use of botulinum toxin type F injections to treat torticollis in patients with immunity to botulinum toxin type A.

Abstract

Fifteen patients with torticollis who had been treated with repeated injections of botulinum toxin type A (botox A) developed antibodies to the toxin. This resulted in loss of benefit in the 13 patients who had improved with botox A injections and failure to develop muscle atrophy after injection in all 15 patients. Patients were then injected with botulinum toxin type F (botox F) in the same muscles that had been injected with botox A. Ten of the 15 improved after botox F injections, including 9 of the 12 patients who had improved with type A toxin. Six of 9 patients with pain had improvement in pain after botox F injections. Patients reported similar improvement with type F and type A toxins, but duration of benefit was approximately 3 months with type A and approximately 1 month with type F. Botox F is an effective treatment for torticollis in patients who are immune to botox A. The usefulness of type F toxin, however, is limited by short duration of benefit.

• Authors: P E Greene, S Fahn
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 8 Issue 4 Pg. 479-83 (Oct 1993) ISSN: 0885-3185 [Print] United States
• PMID: 8232357 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Immunotoxins
• Botulinum Toxins

Topics

• Adolescent
• Adult
• Antibody Formation
• Botulinum Toxins (classification, immunology, therapeutic use)
• Dystonia (drug therapy, immunology)
• Female
• Humans
• Immunity
• Immunotoxins
• Male
• Torticollis (drug therapy, immunology)