Abstract | BACKGROUND: METHODS AND RESULTS:
Aspirin (325 mg bid) or heparin (5000-U intravenous bolus followed by a perfusion titrated to the APTT) were compared in a double-blind randomized trial of 484 patients in two cohorts enrolled sequentially. The study was initiated at admission to hospital at a mean of 8.3 +/- 7.8 hours after the last episode of pain. End points were assessed 5.7 +/- 3.3 days later, when the decision for long-term management was made. Myocardial infarction occurred in 2 (0.8%) of the 240 patients randomized to heparin and in 9 (3.7%) of the 244 randomized to aspirin (P = .035), an odds ratio of 0.22 and a risk difference of 2.9% (95% confidence limits, 0.3% to 5.6%) with heparin. The only death resulted from a myocardial infarction in an aspirin patient. Survival curves with Cox logistic regression analysis showed that the improvement in survival without myocardial infarction with heparin (P = .035) was independent of other baseline characteristics. CONCLUSIONS:
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Authors | P Théroux, D Waters, S Qiu, J McCans, P de Guise, M Juneau |
Journal | Circulation
(Circulation)
Vol. 88
Issue 5 Pt 1
Pg. 2045-8
(Nov 1993)
ISSN: 0009-7322 [Print] United States |
PMID | 8222097
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Acute Disease
- Angina, Unstable
(complications, drug therapy)
- Aspirin
(therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
- Factor Analysis, Statistical
- Female
- Heparin
(therapeutic use)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(etiology, prevention & control)
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