Abstract |
Brodimoprim was studied in the treatment of acute respiratory tract infections in hospitalized, basically healthy, military conscripts. Its efficacy and tolerance were compared to those of doxycycline in a clinical randomized double-blind trial. 60 pts. were divided into two equally large groups. One group received brodimoprim, 400 mg as a loading dose followed by 200 mg daily, for 10 days. The other group received doxycycline, 200 mg as a loading dose followed by 100 mg daily, for 10 days. In the brodimoprim group, 23 patients (77%) were cured, 5 patients (16%) improved and 2 patients (6%) were considered failures. In the doxycycline group, 26 patients (87%) were cured, 3 patients (10%) improved and 1 patient (3%) did not respond. The only side effect in the whole study was moderate diarrhea in 1 patient in the brodimoprim group. Clinically and according to the normalization of laboratory values, the two drugs tested were equally effective.
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Authors | H A Salmi |
Journal | Journal of chemotherapy (Florence, Italy)
(J Chemother)
Vol. 5
Issue 6
Pg. 532-6
(Dec 1993)
ISSN: 1120-009X [Print] England |
PMID | 8195852
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Trimethoprim
- Doxycycline
- brodimoprim
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Topics |
- Acute Disease
- Adolescent
- Adult
- Body Temperature
- Cough
(drug therapy)
- Double-Blind Method
- Doxycycline
(pharmacology, therapeutic use)
- Drug Tolerance
- Humans
- Length of Stay
- Leukocyte Count
(drug effects)
- Leukocytes
(cytology, drug effects)
- Male
- Mycoplasma Infections
(blood, drug therapy)
- Neutrophils
(cytology, drug effects)
- Respiration
(drug effects, physiology)
- Respiratory Tract Infections
(drug therapy, microbiology, physiopathology)
- Trimethoprim
(analogs & derivatives, pharmacology, therapeutic use)
- Virus Diseases
(blood, drug therapy)
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