Anti-inflammatory and analgetic effects of indomethacin following removal of impacted mandibular third molars.

Abstract

In a double-blind, clinical study, the analgetic and anti-inflammatory effects of indomethacin (Indocid) were evaluated following removal of impacted or semi-impacted mandibular third molars in 50 patients. Regarding analgetic effectiveness, 84% of the patients reported good or excellent relief from pain after administration of 50 mg of indomethacin three times a day for 2 days. The analgetic effect of indomethacin was significantly better than that of placebo. There was no significant difference in anti-inflammatory effectiveness between indomethacin and placebo. The degree of trismus postoperatively was significantly less in the indomethacin group. Due to a rather high incidence of side effects (28%) in the central nervous system and the gastrointestinal tract, the routine use of indomethacin in oral surgery is not recommended.

• Authors: J K Petersen
• Journal: International journal of oral surgery (Int J Oral Surg) Vol. 4 Issue 6 Pg. 267-76 (Dec 1975) ISSN: 0300-9785 [Print] Denmark
• PMID: 815189 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Placebos
• Indomethacin

Topics

• Administration, Oral
• Adolescent
• Adult
• Clinical Trials as Topic
• Female
• Humans
• Indomethacin (administration & dosage, adverse effects, therapeutic use)
• Male
• Middle Aged
• Molar
• Pain (drug therapy)
• Placebos
• Surgical Wound Infection (prevention & control)
• Tooth Extraction
• Tooth, Impacted (surgery)