[Carbamazepine poisoning: protracted course with development of intestinal atony and hepatic toxicity].

Abstract

A 43 year-old female patient with a history of manic-depressive illness and prophylactic carbamazepine (CBZ) medication ingested a potentially lethal overdose of 20 g of the substance. Neurotoxic symptoms reached full intensity after about 24 hours. Subsequently, the patient developed a gastrointestinal atony, which proved to be refractory to treatment for several days. Moreover, there was an increase of bilirubin. Parallel to this we observed the persistence-and even intermittent re-increase--of toxic serum CBZ concentrations for one week with corresponding protracted clinical symptomatology.

• Authors: W Baischer, A Wagner, D Seidler, M Musalek, A Laggner
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 106 Issue 1 Pg. 27-9 ( 1994) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Intoxikation mit Carbamazepin: Protrahierter Verlauf unter Entwicklung von Darmatonie und Hepatotoxizität.
• PMID: 8135028 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carbamazepine

Topics

• Adult
• Bipolar Disorder (blood, drug therapy, psychology)
• Carbamazepine (pharmacokinetics, poisoning, therapeutic use)
• Chemical and Drug Induced Liver Injury (blood, etiology)
• Coma (blood, chemically induced)
• Drug Overdose (blood, etiology)
• Female
• Humans
• Intestinal Pseudo-Obstruction (blood, chemically induced)
• Metabolic Clearance Rate (physiology)
• Neurologic Examination (drug effects)
• Peristalsis (drug effects)
• Suicide, Attempted (psychology)