[Pharmacology of a new cardiotropic drug : (dichloro-2, 3-methoxy 4) phenyl furyl-2-0-(diethylamino-ethyl)-ketone-oxime (ANP 4364)].

Abstract

The (dichloro-2,3 methoxy 4) phenyl furyl-2 0-(diethylaminoethyl)-cetone-oxime (ANP 4364) is a powerful coronary vasodilator which lowers the resistance of large coronary arteries and decreases the O2 consumption of the myocardium. The activity of ANP 4364 is similar to digitalis: increase of cardiac flow, bradycardia, redistribution of the blood to peripheral area. These properties demonstrated in dogs have been confirmed in patients with cardiac diseases.

• Authors: P Bessin, J Thuillier
• Journal: Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles (C R Acad Hebd Seances Acad Sci D) 1975 Aug 4-25 Vol. 281 Issue 5-8 Pg. 463-6 France
• Vernacular Title: Pharmacologie d'un nouveau cardiotrope: le (dichloro-2,3 méthoxy 4) phényl furyl-2 0-(diéthylamino-éthyl)-cétone-oxime (ANP 4364)
• PMID: 809213 (Publication Type: English Abstract, Journal Article)

Chemical References

• Benzofurans
• Vasodilator Agents

Topics

• Animals
• Aorta
• Benzofurans (pharmacology)
• Blood Pressure (drug effects)
• Cardiac Output (drug effects)
• Coronary Circulation (drug effects)
• Depression, Chemical
• Dogs
• Heart (drug effects)
• Heart Rate (drug effects)
• Male
• Oxygen Consumption (drug effects)
• Stimulation, Chemical
• Vascular Resistance (drug effects)
• Vasodilator Agents (pharmacology)
• Vertebral Artery