Recovery after dietary vitamin E supplementation of impaired endothelial function in vitamin E-deficient rats.

Abstract

1. Thoracic aortae, isolated from rats supplemented with dietary vitamin E after vitamin E deficiency, were analysed for changes in vascular reactivity. 2. Following 4 or 12 months of dietary vitamin E deficiency, endothelium-dependent vasodilator responses to acetylcholine were significantly impaired. However, when animals were fed after the first 4 months of vitamin E deprivation with a vitamin E-supplemented diet for 8 months, endothelium-mediated responses were completely restored. 3. In contrast, the endothelium-independent vasodilator or vasoconstrictor responses to sodium nitroprusside and noradrenaline, respectively were not altered either by vitamin E deficiency or supplementation. 4. These data indicate that vitamin E supplementation reversed the impairment of endothelial cell function which occurs during vitamin E deficiency.

• Authors: A Rubino, G Burnstock
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 112 Issue 2 Pg. 515-8 (Jun 1994) ISSN: 0007-1188 [Print] England
• PMID: 8075870 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamin E
• Nitroprusside
• Acetylcholine
• Norepinephrine

Topics

• Acetylcholine (pharmacology)
• Animals
• Aorta, Thoracic (drug effects)
• Endothelium, Vascular (physiopathology)
• In Vitro Techniques
• Male
• Muscle Contraction (drug effects)
• Muscle, Smooth, Vascular (drug effects)
• Nitroprusside (pharmacology)
• Norepinephrine (pharmacology)
• Rats
• Rats, Wistar
• Vasodilation (drug effects)
• Vitamin E (therapeutic use)
• Vitamin E Deficiency (drug therapy, physiopathology)