Abstract |
Changes in local cerebral glucose utilization (LCGU) of the postischemic rat brain were investigated using the rat four-vessel occlusion model. Following 20 or 30 min of ischemia, LCGUs of the cerebral cortices, striatum and hippocampus were decreased at 1 and 3 days postischemia, but were recovered at 7 days postischemia. Effects of repeated administration of RS-8359, (+-)-4-(4-cyanoanilino)-7-hydroxycyclopenta(3,2-e)pyrimidin e, (30 mg/kg x 2/day, p.o., 4 days) were examined at 3 days postischemia following 20 min of ischemia. Compared with the sham-operated group, the LCGUs of 22 out of 34 structures examined in the ischemic-control group were significantly reduced. In the RS-8359-treated group, however, significant reduction was observed in only 9 structures. Compared with the ischemic-control group, RS-8359 significantly ameliorated the reduction of LCGU in 12 structures. These results suggest that RS-8359 has beneficial effects on reduced glucose metabolism in the postischemic brain.
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Authors | M Kozuka, K Kobayashi, N Iwata |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 64
Issue 4
Pg. 257-64
(Apr 1994)
ISSN: 0021-5198 [Print] Japan |
PMID | 8057526
(Publication Type: Journal Article)
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Chemical References |
- Nitriles
- Pyrimidines
- RS 8359
- Glucose
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Topics |
- Animals
- Brain
(drug effects, metabolism)
- Glucose
(metabolism)
- Ischemic Attack, Transient
(metabolism)
- Male
- Nitriles
(pharmacology)
- Pyrimidines
(pharmacology)
- Rats
- Rats, Wistar
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