[Experimental studies on peripheral-type benzodiazepine receptors in brain in rats with hepatic encephalopathy].

Abstract

By means of radioligand binding assay, peripheral-type benzodiazepine receptors (PBR) in the telencephalon, diencephalon, brain stem and cerebellum, were investigated in a rat model with hepatic encephalopathy (HE). Binding to PBR was studied using [3H]PK11195 as radioligand. It was demonstrated that only densities (Bmax) of [3H]PK11195 binding to crude synaptosomal membranes in the telencephalon, diencephalon of HE rats were obviously increased as compared with those of controls (P < 0.001 and P < 0.05 respectively). Increased affinities (Kd) were only observed in brain stem (P < 0.05). The results showed that the alterations of PBR in different regions of the brain play a significant role in the pathogenesis of HE.

• Authors: Z M Zhang, F Z Qiu, X P Chen
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 32 Issue 1 Pg. 37-40 (Jan 1994) ISSN: 0529-5815 [Print] China
• PMID: 8045200 (Publication Type: English Abstract, Journal Article)

Chemical References

• Receptors, GABA-A

Topics

• Animals
• Brain Chemistry
• Hepatic Encephalopathy (metabolism)
• Liver Failure (complications)
• Male
• Radioligand Assay
• Rats
• Rats, Sprague-Dawley
• Receptors, GABA-A (analysis)