[An analysis of the results of clinical trials of praziquantel analogs in intestinal cestode and trematode infections. 1. The treatment of intestinal cestode infections (diphyllobothriasis, taeniasis, hymenolepiasis)].

Abstract

The studies have demonstrated a high efficacy of prasiquantel in therapy of enteric cestodiases. No differences in the efficacy and tolerance of prasiquantel analogs manufactured by various pharmaceutic firms (azinox, CIS; pikiton, China; biltricide, Bayer, India; cesol, Merk, India; cisticide, Merk India) were detected. Prasiquantel single dose (15 mg/kg) efficacies in diphyllobothriasis, taeniarhynchiasis, and taeniasis made up 91.4, 98.5, and 100%, respectively. In hymenolepiasis the efficacy of a total dose (40 and 50 mg/kg given twice with a 10-day interval) was 88.9%.

• Authors: A M Bronshteĭn, L I Mel'nikova, R A Firsova, Iu A Legon'kov
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1993 May-Jun Issue 3 Pg. 27-9 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Analiz rezul'tatov klinicheskikh ispytaniĭ analogov prazikvantelia pri kishechnykh tsestodozakh i trematodozakh. 1. Lechenie kishechnykh tsestodozov (difillobrotrioz, teniidozy, gimenolepidoz).
• PMID: 8041313 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Praziquantel

Topics

• Adolescent
• Adult
• Aged
• Diphyllobothriasis (drug therapy, parasitology, transmission)
• Female
• Humans
• Hymenolepiasis (drug therapy, parasitology, transmission)
• Male
• Middle Aged
• Parasite Egg Count
• Praziquantel (adverse effects, analogs & derivatives, therapeutic use)
• Taeniasis (drug therapy, parasitology, transmission)
• Time Factors
• Trematode Infections (drug therapy, parasitology, transmission)