[A case of minocycline-induced pneumonitis with bronchial asthma].

Abstract

We report a case of minocycline-induced pneumonitis. A 30-year-old woman was treated with minocycline for mycoplasma pneumonia of the right upper lobe. About 15 days after starting treatment, she developed a productive cough, stridor, and dyspnea. The chest X-ray film showed pulmonary infiltration in the left middle lung field. Based on the clinical history and the detection of eosinophilia in the bronchoalveolar fluid, drug-induced pneumonitis was suspected. Treatment with minocycline was discontinued and prednisolone (20 mg/day) was started, after which her symptoms subsided and there was marked regression of the pulmonary infiltrates on chest X-ray films. The lymphocyte stimulation test for minocycline was negative, but the diagnosis was confirmed by a positive oral provocation test.

• Authors: T Haruna, Y Mochizuki, Y Nakahara, R Kawanami, T Kawamura, H Hashimoto, K Tsuyuguchi, Y Matsushita
• Journal: Nihon Kyobu Shikkan Gakkai zasshi (Nihon Kyobu Shikkan Gakkai Zasshi) Vol. 32 Issue 7 Pg. 671-5 (Jul 1994) ISSN: 0301-1542 [Print] Japan
• PMID: 7967242 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Minocycline

Topics

• Adult
• Asthma (chemically induced)
• Drug Hypersensitivity (etiology)
• Female
• Humans
• Minocycline (adverse effects)
• Pneumonia (chemically induced)
• Respiratory Hypersensitivity (chemically induced)