The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia.

Abstract

The ability of the selective metabotropic glutamate receptor (mGluR) antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) to protect hippocampal CA1 neurons from a hypoxic/hypoglycemic injury was examined. Rat hippocampal slices were exposed to a 4 min hypoxia/hypoglycemia, and the recovery of evoked population spikes was monitored. 500 microM (+)-MCPG exhibited a statistically significant protective effect, whereas the (-)-isomer was ineffective. These data suggest that MCPG-sensitive mGluRs may contribute to hypoxia/hypoglycemia-induced injury in rat hippocampal slices.

• Authors: T Opitz, P Richter, K G Reymann
• Journal: Neuropharmacology (Neuropharmacology) Vol. 33 Issue 5 Pg. 715-7 (May 1994) ISSN: 0028-3908 [Print] England
• PMID: 7936108 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzoates
• Receptors, Metabotropic Glutamate
• alpha-methyl-4-carboxyphenylglycine
• Glucose
• Glycine

Topics

• Animals
• Benzoates (pharmacology)
• Glucose (metabolism)
• Glycine (analogs & derivatives, pharmacology)
• Hippocampus (cytology, drug effects)
• Hypoglycemia (physiopathology)
• Hypoxia (physiopathology)
• In Vitro Techniques
• Neurons (drug effects)
• Oxygen Consumption (drug effects)
• Rats
• Rats, Wistar
• Receptors, Metabotropic Glutamate (antagonists & inhibitors)
• Signal Transduction (drug effects)
• Stereoisomerism