Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy.

Abstract

Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy.

• Authors: Y Takeuchi, Y Miyanomae, H Komatsu, Y Oomizono, A Nishimura, S Okano, T Nishiki, T Sawada
• Journal: Journal of child neurology (J Child Neurol) Vol. 9 Issue 3 Pg. 287-9 (Jul 1994) ISSN: 0883-0738 [Print] United States
• PMID: 7930408 (Publication Type: Case Reports, Journal Article)

Chemical References

• Thyrotropin-Releasing Hormone

Topics

• Age of Onset
• Child
• Child, Preschool
• Electromyography
• Humans
• Infant
• Infant, Newborn
• Male
• Median Nerve
• Motor Neurons (drug effects)
• Severity of Illness Index
• Spinal Muscular Atrophies of Childhood (drug therapy)
• Thyrotropin-Releasing Hormone (pharmacology, therapeutic use)
• Tibial Nerve
• Treatment Outcome