An improved DNA-based identification of fetuses at risk for HPA-1a (PlA1) neonatal alloimmune thrombocytopenia.

Abstract

A simple and reliable procedure, based on DNA amplification and HpaII mapping, is proposed for the identification of fetuses at risk for HPA-1a (PlA1) neonatal alloimmune thrombocytopenia which could cause life-threatening haemorrhage, even in early fetal life. This typing procedure for HPA-1 alleles should help in deciding, very early, the therapeutic management of the fetuses at risk.

• Authors: S Clemenceau, B Perichon, J Elion, C Kaplan, R Krishnamoorthy
• Journal: British journal of haematology (Br J Haematol) Vol. 86 Issue 1 Pg. 198-200 (Jan 1994) ISSN: 0007-1048 [Print] England
• PMID: 7912098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Human Platelet
• ITGB3 protein, human
• Integrin beta3
• DNA

Topics

• Antigens, Human Platelet (analysis)
• Base Sequence
• Blood Platelets (immunology)
• DNA (chemistry)
• Female
• Fetal Diseases (diagnosis, genetics)
• Humans
• Integrin beta3
• Molecular Sequence Data
• Polymerase Chain Reaction (methods)
• Polymorphism, Restriction Fragment Length
• Pregnancy
• Thrombocytopenia (diagnosis, genetics)