Abstract |
This study measured the changes in uterine volume, uterine vascular resistive index and lumbar vertebral bone density before and after a six-month course of leuprolide acetate depot in women with uterine leiomyomas. All nine patients studied were black. The high baseline bone density of black women may provide a greater scope for the use of gonadotropin agonists as compared to women in the general population. A significant reduction in uterine volume was achieved in the patients with leuprolide therapy. Uterine vascular resistive indices were not altered consistently following leuprolide therapy in women with leiomyomas.
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Authors | M E Rivlin, R B Patel, L W Hess, D B Hess, G R Meeks |
Journal | The Journal of reproductive medicine
(J Reprod Med)
Vol. 39
Issue 9
Pg. 663-6
(Sep 1994)
ISSN: 0024-7758 [Print] United States |
PMID | 7807474
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Delayed-Action Preparations
- Leuprolide
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Topics |
- Adult
- Black People
- Bone Density
(drug effects)
- Delayed-Action Preparations
- Female
- Humans
- Leiomyoma
(diagnosis, drug therapy, pathology, physiopathology)
- Leuprolide
(pharmacology, therapeutic use)
- Organ Size
(drug effects)
- Uterine Neoplasms
(diagnosis, drug therapy, pathology, physiopathology)
- Vascular Resistance
(drug effects)
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