[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines].

Abstract

The paper describes the synthesis of 6-[4-alkylpiperazinyl-1)phenylamino]-1,2,5-thiadiazolo[3,4-h ]quinolines where methyl (Drug G-1574) and ethyl (Drug G-1569) are alkyls. The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.5-5 times lower than the effective dose of phenasal (niclosamide).

• Authors: F S Mikhaĭlitsyn, F P Kovalenko, N P Kozyreva, V I Dzhabarova, M N Lebedeva, N D Lychko, A S Naĭdenova, N A Uvarova
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1994 Jul-Sep Issue 3 Pg. 41-4 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Izyskanie novykh protivoparazitarnykh sredstv. 12. Sintez i izuchenie protivoékhinokokkoznoĭ i protivogimenolepidoznoĭ aktivnosti 6-[4-(4-alkilpiperazinil-1)-fenilamino]-1,2,5-tiadiazolo[3,4-h] khinolinov.
• PMID: 7799857 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticestodal Agents
• Quinolines
• Mebendazole
• Niclosamide

Topics

• Animals
• Anticestodal Agents (chemical synthesis, therapeutic use, toxicity)
• Drug Evaluation, Preclinical
• Echinococcosis (drug therapy, parasitology)
• Female
• Hymenolepiasis (drug therapy, parasitology)
• Male
• Mebendazole (therapeutic use)
• Mice
• Niclosamide (therapeutic use)
• Quinolines (chemical synthesis, therapeutic use, toxicity)
• Sigmodontinae