[The pharmacokinetics and pharmacodynamics of prophylactic doses of aspirin in pregnant women from a group at risk for placental insufficiency].

Abstract

The pharmacokinetics and pharmacodynamics of small-dose aspirin (60 mg/day) were studied during the second to the third trimesters in pregnant females at a high risk of placental insufficiency. In the group of pregnant women with uncomplicated pregnancies (n = 16), the aspirin kinetic changes which presented with a lower concentration-time index, higher total clearance and larger distribution volume were associated with the gestational age. Similar changes were revealed in the group of pregnant women (n = 4) with advanced placental insufficiency. The findings suggest that the optimal therapeutical aspirin doses should be chosen by the gestational age rather than by the severity of placental insufficiency.

• Authors: G U Asymbekova, P D Banartsev, T B Ochan, B E Rozenfel'd, A K Sariev, I Iu Folomeeva, S V Pavlovich
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1995 Mar-Apr Vol. 58 Issue 2 Pg. 35-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Farmakokinetika i farmakodinamika profilakticheskikh doz aspirina u beremennykh gruppy riska po platsentarnoĭ nedostatochnosti.
• PMID: 7773087 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aspirin

Topics

• Adult
• Aspirin (administration & dosage, pharmacokinetics, pharmacology)
• Blood Platelets (drug effects, ultrastructure)
• Blood Viscosity (drug effects)
• Drug Evaluation
• Female
• Humans
• Placental Insufficiency (blood, diagnostic imaging, prevention & control)
• Pregnancy
• Pregnancy Trimester, Second
• Pregnancy Trimester, Third
• Risk Factors
• Time Factors
• Ultrasonography, Prenatal