Abstract |
1. The role of allopurinol in the protection of kidney function following ischaemia- reperfusion injury has been investigated using the novel technique of near-infrared spectroscopy. 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. 3. Allopurinol infusion increased the rate of reperfusion of oxygenated blood seen in control rats (P < 0.05). 4. Allopurinol enhanced the rate of tissue oxygenation during early reperfusion (P < 0.01). 5. This study provides further evidence for the proposed benefits of allopurinol in ischaemia- reperfusion injury. Furthermore, the potential of near-infrared spectroscopy as a technique of value in interventional studies of this nature is confirmed.
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Authors | D L Vaughan, Y A Wickramasinghe, G I Russell, M S Thorniley, R F Houston, E Ruban, P Rolfe |
Journal | Clinical science (London, England : 1979)
(Clin Sci (Lond))
Vol. 88
Issue 3
Pg. 359-64
(Mar 1995)
ISSN: 0143-5221 [Print] England |
PMID | 7736707
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hemoglobins
- Oxyhemoglobins
- Allopurinol
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Topics |
- Allopurinol
(therapeutic use)
- Animals
- Hemoglobins
(metabolism)
- Ischemia
(blood, pathology, therapy)
- Kidney
(blood supply, pathology)
- Male
- Oxyhemoglobins
(metabolism)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(blood, pathology, prevention & control)
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