Abstract | BACKGROUND: METHOD: A six-week case-controlled study with repeated overnight blood sampling was conducted. Ten patients fulfilling the criteria for major depressive disorder, seasonal type, with a 29-item Hamilton Depression Rating Scale (HDRS) score of at least 20 were compared with ten age- and sex-matched healthy controls in a clinical laboratory. The effects of fluoxetine (20 mg/day) on the HDRS and melatonin concentration were measured. RESULTS:
Fluoxetine significantly reduced melatonin levels in both groups. There was no significant difference in melatonin secretion between the groups. CONCLUSIONS:
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Authors | P A Childs, I Rodin, N J Martin, N H Allen, L Plaskett, P J Smythe, C Thompson |
Journal | The British journal of psychiatry : the journal of mental science
(Br J Psychiatry)
Vol. 166
Issue 2
Pg. 196-8
(Feb 1995)
ISSN: 0007-1250 [Print] England |
PMID | 7728363
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Adrenergic, beta-1
- Fluoxetine
- Melatonin
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Topics |
- Adult
- Female
- Fluoxetine
(pharmacology, therapeutic use)
- Humans
- Hypothalamus
(drug effects)
- Male
- Melatonin
(metabolism)
- Receptors, Adrenergic, beta-1
(drug effects)
- Seasonal Affective Disorder
(drug therapy)
- Treatment Outcome
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