Abstract | OBJECTIVE: DESIGN: An international, multicentre, randomized double-blind, parallel-group controlled trial. SETTING: Outpatient clinics at 20 tertiary care medical centres in 11 countries. PATIENTS: One hundred and thirty-five patients with uncomplicated primary hypertension with a history of ACE inhibitor-related cough were randomly assigned to the double-blind treatment phase and completed the study. INTERVENTION: MAIN OUTCOME MEASURES:
Cough incidence, severity and frequency were assessed by a self-administered questionnaire and a visual analogue scale. RESULTS: CONCLUSION: The incidence of cough related to the type 1 Ang II receptor antagonist losartan is significantly lower than that observed with lisinopril, and similar to that observed with hydrochlorothiazide in patients with a rechallenged ACE inhibitor cough. Type 1 Ang II receptor antagonists represent a potential new treatment for hypertensive patients in whom ACE inhibitors are indicated, but who develop a cough with these agents.
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Authors | Y Lacourcière, H Brunner, R Irwin, B E Karlberg, L E Ramsay, D B Snavely, T W Dobbins, E P Faison, E B Nelson |
Journal | Journal of hypertension
(J Hypertens)
Vol. 12
Issue 12
Pg. 1387-93
(Dec 1994)
ISSN: 0263-6352 [Print] England |
PMID | 7706699
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin Receptor Antagonists
- Biphenyl Compounds
- Imidazoles
- Tetrazoles
- Hydrochlorothiazide
- Lisinopril
- Losartan
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Topics |
- Adult
- Aged
- Angiotensin Receptor Antagonists
- Biphenyl Compounds
(adverse effects)
- Cough
(chemically induced)
- Double-Blind Method
- Female
- Humans
- Hydrochlorothiazide
(adverse effects)
- Hypertension
(drug therapy)
- Imidazoles
(adverse effects)
- Lisinopril
(adverse effects)
- Losartan
- Male
- Middle Aged
- Prospective Studies
- Renin-Angiotensin System
(drug effects)
- Tetrazoles
(adverse effects)
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