Abstract |
1. Samples of urine from two human subjects accidentally exposed to sulphur mustard were analysed for metabolites derived from hydrolysis ( thiodiglycol, thiodiglycol sulphoxide), conjugation with glutathione (1,1'-sulphonylbis [2-S-(N-acetylcysteinyl) ethane]) and from further metabolism of glutathione conjugates by the beta- lyase pathway (1,1-sulphonylbis[2-(methylsulphinyl) ethane], 1-methylsulphinyl-2-[2-(methylthio)ethylsulphonyl] ethane). 2. Thiodiglycol sulphoxide was excreted in much higher concentrations than thiodiglycol, as was observed previously in rat exposed to sulphur mustard. However, the use of thiodiglycol sulphoxide as a biological marker for sulphur mustard poisoning is limited by its presence at low concentrations in normal human urine. 3. beta- lyase metabolites were detected at concentrations comparable with those of thiodiglycol sulphoxide. No background levels of beta- lyase metabolites have been detected in normal human urine, and they are proposed as unequivocal diagnostic and forensic indicators of sulphur mustard poisoning in man.
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Authors | R M Black, R W Read |
Journal | Xenobiotica; the fate of foreign compounds in biological systems
(Xenobiotica)
Vol. 25
Issue 2
Pg. 167-73
(Feb 1995)
ISSN: 0049-8254 [Print] England |
PMID | 7618344
(Publication Type: Journal Article)
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Chemical References |
- Sulfhydryl Compounds
- Sulfoxides
- 2,2'-sulfinylbisethanol
- 2,2'-thiodiethanol
- Lyases
- Mustard Gas
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Topics |
- Biotransformation
- Humans
- Hydrolysis
- Lyases
(urine)
- Male
- Molecular Structure
- Mustard Gas
(pharmacokinetics)
- Sulfhydryl Compounds
(urine)
- Sulfoxides
(urine)
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