Kainate/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats.

Abstract

Non-NMDA receptor antagonists CNQX, DNQX, and NBQX (10-40 mg/kg IP) were tested against pentylenetetrazol-induced (100 mg/kg SC) seizures in 7 to 90-day-old rats. All three drugs significantly decreased the incidence of tonic hindlimb component of tonic-clonic pentylenetetrazol seizures, often in favor of increased incidence of forelimb tonus throughout development. In addition, in 7 to 25-day-old rats, DNQX and NBQX decreased the severity of seizures due to a decrease in total incidence of the tonic component of tonic-clonic seizures compared to age-matched controls. However, neither drug was able to consistently suppress the incidence or increase latency to onset of clonic and tonic-clonic pentylenetetrazol seizures. The data suggest that, during development, non-NMDA receptor transmission may play a role in the generation of the tonic component, but not in the generation of other components of pentylenetetrazol-induced seizures.

• Authors: L Velísek, H Kubová, P Mares, D Vachová
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 51 Issue 1 Pg. 153-8 (May 1995) ISSN: 0091-3057 [Print] United States
• PMID: 7617727 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Quinoxalines
• Receptors, AMPA
• Receptors, Kainic Acid
• 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
• FG 9041
• 6-Cyano-7-nitroquinoxaline-2,3-dione
• Pentylenetetrazole

Topics

• 6-Cyano-7-nitroquinoxaline-2,3-dione (pharmacology)
• Aging (physiology)
• Animals
• Anticonvulsants (pharmacology)
• Behavior, Animal (drug effects)
• Epilepsy, Tonic-Clonic (chemically induced, prevention & control)
• Hindlimb (drug effects, physiology)
• Male
• Muscle Tonus (drug effects)
• Pentylenetetrazole
• Quinoxalines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, AMPA (antagonists & inhibitors)
• Receptors, Kainic Acid (antagonists & inhibitors)
• Seizures (chemically induced, prevention & control)
• Synaptic Transmission (drug effects)