Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes.

Abstract

The effects of reducing stress on glucose metabolism in diabetics were evaluated in 20 patients with type 2 diabetes (10 of each sex) who were given an anxiolytic (fludiazepam) for 12 weeks. Patients were tested 4 weeks before the start of anxiolytic treatment (A), immediately before the first dose (B), and before the end of the study period (C) using the State-Trait Anxiety Index and glycosylated haemoglobin levels. There were no significant differences between the trait or state anxiety scores or the glycosylated haemoglobin levels at times A and B before treatment. However, for all three measurements, the values at time C, after treatment, showed significant improvements, compared with those at both times A and B (P < 0.05). The improvement in the trait anxiety score was weakly correlated with the decrease in the glycosylated haemoglobin level (r = 0.426, P < 0.01). No correlation was seen between state anxiety scores and glycosylated haemoglobin levels. The results suggest that suppressing anxiety in patients with type 2 diabetes reduces glycosylated haemoglobin levels.

• Authors: S Okada, K Ichiki, S Tanokuchi, K Ishii, H Hamada, Z Ota
• Journal: The Journal of international medical research (J Int Med Res) 1995 Mar-Apr Vol. 23 Issue 2 Pg. 119-22 ISSN: 0300-0605 [Print] England
• PMID: 7601294 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Anxiety Agents
• Glycated Hemoglobin A
• Benzodiazepines
• fludiazepam
• Diazepam

Topics

• Adult
• Aged
• Anti-Anxiety Agents (therapeutic use)
• Anxiety (blood, diagnosis, drug therapy)
• Benzodiazepines
• Diabetes Mellitus, Type 2 (blood, complications)
• Diazepam (analogs & derivatives, therapeutic use)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Psychological Tests
• Stress, Psychological (blood, complications, drug therapy)
• Treatment Outcome