Abstract | OBJECTIVES: BACKGROUND: Exercise and pharmacologic stress echocardiography are clinically accepted techniques for detecting coronary artery disease. Arbutamine is a new synthetic beta- adrenoceptor agonist developed specifically as a stress agent. Arbutamine is delivered by a new computerized drug delivery device that adjusts the rate of drug infusion according to the patient's heart rate response during stress testing. METHODS: The sensitivity of arbutamine echocardiography was determined in 143 patients who had coronary artery disease documented by coronary angiography. A subset of these patients (n = 114) also underwent exercise echocardiography. The specificity, or normalcy, of arbutamine echocardiography was determined in 54 patients considered to have a low likelihood of coronary artery disease. RESULTS: Among those patients who had both stress test results, the incidence of inducing myocardial ischemia (new or worsening wall motion abnormalities) was 79% (95% confidence interval [CI] 69% to 86%, n = 98) for arbutamine and 77% (95% CI 67% to 85%, n = 98) for exercise echocardiography. The sensitivity of detecting coronary artery disease ( ischemia or rest wall motion abnormality) was 87% (95% CI 79% to 93%, n = 101) for arbutamine and 83% (95% CI 74% to 90%, n = 101) for exercise echocardiography. The specificity (normalcy) of arbutamine echocardiogrpahy was 96% (95% CI 87% to 100%, n = 52). Arbutamine was well tolerated, and there were no serious adverse events. CONCLUSIONS:
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Authors | J L Cohen, K L Chan, W Jaarsma, D S Bach, D W Muller, M R Starling, W F Armstrong |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 26
Issue 5
Pg. 1168-75
(Nov 01 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7594028
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cardiotonic Agents
- Catecholamines
- arbutamine
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Topics |
- Cardiotonic Agents
(adverse effects)
- Catecholamines
(adverse effects)
- Coronary Disease
(diagnosis)
- Echocardiography
- Exercise Test
- Humans
- Myocardial Ischemia
(chemically induced)
- Sensitivity and Specificity
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