Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma.
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| Abstract |
We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3%-p = 0.0027). One of the HIV-1-positive and none of the HIV-1-negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-II or a closely homologous retrovirus infects a high proportion of patients with AIDS-associated NHL.
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| Authors | G Zehender, L Meroni, S Piconi, C De Maddalena, C Parravicini, M Clerici, A L Ridolfo, M Moroni, M Galli |
| Journal | AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 11 Issue 7 Pg. 823-7 (Jul 1995) ISSN: 0889-2229 [Print] United States |
| PMID | 7546909 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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