Dobutamine echocardiography in predicting improvement in global left ventricular systolic function after coronary bypass or angioplasty in patients with healed myocardial infarcts.

Abstract	The aim of this study was to determine whether low-dose dobutamine echocardiography (DE) could predict quantitative improvement in global left ventricular (LV) systolic function after coronary revascularization. Low-dose DE was performed in 71 consecutive patients with coronary artery disease and LV dysfunction. Successful coronary bypass surgery or angioplasty was performed in 44 patients, 37 of whom had a resting echocardiogram 1 to 3 months afterward. Group A consisted of 20 patients with contractile reserve during DE, and group B consisted of 17 patients without contractile reserve. As expected, regional wall motion score index (mean +/- SD) improved in group A (1.62 +/- 0.39 to 1.38 +/- 0.31, p < 0.01) but not group B (1.56 +/- 0.42 to 1.57 +/- 0.41, p = NS). In addition, LV ejection fraction (LVEF) improved after bypass surgery or angioplasty in group A (38 +/- 5% to 42 +/- 5%, p < 0.01), but not in group B (38 +/- 7% to 39 +/- 8%, p = NS). In group A, a significant linear correlation was observed between the number of segments with contractile reserve and the improvement in LVEF (r = 0.91, p < 0.0001). A good correlation also existed between the improvement in regional wall motion score index during dobutamine infusion and the improvement in LVEF after bypass surgery or angioplasty (r = 0.90, p < 0.0001). In conclusion, low-dose DE can be used to predict quantitative improvement in global LV systolic function after coronary bypass or angioplasty.
Authors	J Meluzin, C G Cigarroa, M E Brickner, J Cerny, L Spinarova, M Frelich, F Stetka, L Groch, P A Grayburn
Journal	The American journal of cardiology (Am J Cardiol) Vol. 76 Issue 12 Pg. 877-80 (Nov 01 1995) ISSN: 0002-9149 [Print] United States
PMID	7484824 (Publication Type: Journal Article)
Chemical References	Cardiotonic Agents Dobutamine
Topics	Angioplasty, Balloon, Coronary Cardiotonic Agents Coronary Artery Bypass Dobutamine Echocardiography Hemodynamics Humans Middle Aged Myocardial Infarction (diagnostic imaging, physiopathology, surgery) Postoperative Period Predictive Value of Tests Prognosis Stroke Volume Systole Ventricular Function, Left

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