Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly.

Abstract

Plasma glucagon and insulin responses to L-arginine were compared in normal controls and patients with isolated growth hormone deficiency and acromegaly. Patients with isolated growth hormone deficiency were characterized by high plasma glucagon response and low plasma insulin response, whereas acromegalic patients showed exaggerated plasma glucagon response and almost normal insulin response. These results suggest that growth hormone is probably required for optimum function of the islets, and since hyperglucagonaemia was observed in both growth hormone deficiency and acromegaly, metabolic disturbances stemming from the respective primary diseases may affect glucagon secretion.

• Authors: Y Seino, T Taminato, Y Goto, Y Inoue, S Kadowaki, M Hattori, K Mori, Y Kato, S Matsukura, H Imura
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 9 Issue 6 Pg. 563-70 (Dec 1978) ISSN: 0300-0664 [Print] England
• PMID: 747897 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Glucose
• Insulin
• Growth Hormone
• Glucagon
• Arginine

Topics

• Acromegaly (metabolism)
• Adolescent
• Adult
• Arginine (pharmacology)
• Blood Glucose
• Child
• Diabetes Mellitus (metabolism)
• Female
• Glucagon (blood)
• Growth Hormone (deficiency)
• Humans
• Insulin (blood)
• Male
• Middle Aged