Controlled-release diethylpropion hydrochloride used in a program for weight reduction.

Abstract

In a double-blind, placebo-controlled evaluation in obese adults given comparable dietary and exercise recommendations, controlled-release diethylpropion hydrochloride promoted significantly more weight loss than matching placebo. The mean reduction in 12 weeks was 15.9 lb (average 1.32 lb/week) for 12 patients taking diethylpropion hydrochloride, 10.0 lb (0.84 lb/week) for 13 taking placebo, and 12.2 lb for 13 taking drug for two four-week periods separated by four weeks of placebo (1.38 lb/week on active drug and 0.30 lb/week on placebo). Amphetamine-like side effects were virtually absent. Diethylpropion hydrochloride is an effective adjunct to caloric restriction in therapy of obesity.

• Authors: W B Parsons Jr
• Journal: Clinical therapeutics (Clin Ther) Vol. 3 Issue 5 Pg. 329-35 ( 1981) ISSN: 0149-2918 [Print] United States
• PMID: 7471128 (Publication Type: Journal Article)

Chemical References

• Delayed-Action Preparations
• Diethylpropion

Topics

• Adolescent
• Adult
• Body Weight
• Delayed-Action Preparations
• Diet, Reducing
• Diethylpropion (administration & dosage, adverse effects, therapeutic use)
• Double-Blind Method
• Humans
• Middle Aged
• Obesity (drug therapy)
• Physical Exertion