[Changes in lactate dehydrogenase activity and lactic and pyruvic acid concentration in the blood and tissues of animals following intravenous administration of perfluorotributylamine emulsions].

Abstract

Activity of lactate dehydrogenase (LDH) and concentration of lactate and pyruvate were studied in rat and cat tissues after infusion of perfluorotributylamine emulsion. Administration of the emulsion caused an increase in content of lactate and pyruvate as well as LDH activation in the animal blood and tissues. Tissue hypoxia, responsible for stimulation of glycolytic pathway of carbohydrate metabolism, was apparently developed due to transfer of inadequate amount of oxygen by perfluorotributylamine.

• Authors: N I Afonin, N N Doronina, O S Smelova, N L Ivanova, T K Putiatina
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1980 Mar-Apr Vol. 26 Issue 2 Pg. 185-7 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Izmenenie aktivnosti laktatdegidrogenazy i soderzhaniia molochnoĭ i pirovinogradnoĭ kislot v krovi i tkaniakh zhivotnykh posle vnutrivennogo vvedeniia émul'sii perftortributilamina.
• PMID: 7456348 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Blood Substitutes
• Butylamines
• Fluorocarbons
• Lactates
• Pyruvates
• perfluorotributylamine
• L-Lactate Dehydrogenase

Topics

• Animals
• Blood Substitutes (pharmacology)
• Butylamines (pharmacology)
• Cats
• Fluorocarbons (pharmacology)
• Kidney (metabolism)
• L-Lactate Dehydrogenase (metabolism)
• Lactates (analysis)
• Liver (metabolism)
• Lung (metabolism)
• Myocardium (analysis)
• Pyruvates (analysis)
• Rats
• Species Specificity
• Spleen (metabolism)