Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells by N-nitrosocimetidine.

Abstract

N-Nitrosocimetidine (NC) induces significant numbers of sister chromatid exchanges (SCE) and chromosome aberrations in cultured Chinese hamster ovary (CHO) cells even at a concentration of 1.2 x 10(-7) M. Its effectiveness in SCE induction is about two thirds that of the gastric carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). These results constitute further evidence that NC possesses carcinogenic activity.

• Authors: K Athanasiou, S A Kyrtopoulos
• Journal: Cancer letters (Cancer Lett) Vol. 14 Issue 1 Pg. 71-5 (Oct 1981) ISSN: 0304-3835 [Print] Ireland
• PMID: 7296544 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanidines
• Nitroso Compounds
• nitrosocimetidine
• Cimetidine

Topics

• Animals
• Cell Line
• Chromosome Aberrations
• Cimetidine (analogs & derivatives, pharmacology)
• Cricetinae
• Cricetulus
• Crossing Over, Genetic (drug effects)
• Dose-Response Relationship, Drug
• Female
• Guanidines (pharmacology)
• Nitroso Compounds (pharmacology)
• Ovary
• Sister Chromatid Exchange (drug effects)