Copper nitrilotriacetate: a potent therapeutic agent in the treatment of a genetic disorder of copper metabolism.

Abstract

Copper nitrilotriacetate (NTA) was evaluated for its ability to ameliorate effects of the recessive mutant gene crinkled (cr) in mice. Copper-NTA was superior to copper sulfate in increasing postnatal survival and body copper content of offspring of dams supplemented during pregnancy and lactation. Feeding of NTA alone during these periods had no effect on survival. Postnatal supplementation with copper did not increase survival of the mutants. The therapeutic use of copper-NTA, and the necessity for prenatal intervention for successful treatment of the mutant, are discussed in relation to Menkes' syndrome.

• Authors: C L Keen, P Saltman, L S Hurley
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 33 Issue 8 Pg. 1789-1800 (Aug 1980) ISSN: 0002-9165 [Print] United States
• PMID: 7190777 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Sulfates
• Copper
• Zinc
• Nitrilotriacetic Acid
• Copper Sulfate

Topics

• Animals
• Brain Chemistry
• Brain Diseases, Metabolic (drug therapy)
• Copper (analysis, therapeutic use)
• Copper Sulfate
• Female
• Humans
• Kidney (analysis)
• Liver (analysis)
• Male
• Maternal-Fetal Exchange
• Menkes Kinky Hair Syndrome (drug therapy)
• Mice
• Mice, Mutant Strains
• Nitrilotriacetic Acid (therapeutic use)
• Pregnancy
• Sulfates (therapeutic use)
• Zinc (analysis)