[Possibility of preventing muscular dystrophy in E avitaminosis with alpha-tocopheronolactone and diludin].

Abstract

The efficacy of pharmacopeial alpha-tocopheryl acetate, alpha-tocopheronolactone and the antioxidant diludin was studied as to the possibilities of preventing E-hypovitaminosis muscle dystrophy in rabbits. alpha-Tocopheronolactone action was similar to that of pharmacopeial alpha-tocopheryl acetate as regards E-vitamin activity that was manifested by an increase in the body mass, decrease in the urine creatine index and maintenance of normal ubiquinone content, as well as of succinate-ubiquinone-reductase, NADH-ubiquinone-reductase and NADH-cytochrome c-reductase activity of rabbit skeletal muscle and heart mitochondria. On the contrary , as a result of the antioxidant administration, no direct correlation was found between ubiquinone content and activity of ubiquinone-dependent enzymatic systems of mitochondria. The data obtained attest to high E-vitamin activity of alpha-tocopheronolactone. The action of the latter was disclosed to be different from that produced by the antioxidant.

• Authors: V N Kovalenko, G V Donchenko, I V Kuz'menko, N M Gurina, V P Makovetskiĭ
• Journal: Voprosy pitaniia (Vopr Pitan) 1982 Mar-Apr Issue 2 Pg. 44-9 ISSN: 0042-8833 [Print] Russia (Federation)
• Vernacular Title: Izuchenie vozmozhnosti preduprezhdeniia myshechnoĭ distrotii pri E-avitaminoze al'fa-tokoferonolaktonom i diludinom.
• PMID: 7090325 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Pyridines
• etidin
• Ubiquinone
• Vitamin E
• tocopheronolactone
• Dicarbethoxydihydrocollidine
• alpha-Tocopherol
• Tocopherols

Topics

• Animals
• Antioxidants (therapeutic use)
• Dicarbethoxydihydrocollidine (analogs & derivatives, therapeutic use)
• Drug Evaluation, Preclinical
• Mitochondria (metabolism)
• Muscular Dystrophy, Animal (etiology, metabolism, prevention & control)
• Pyridines (therapeutic use)
• Rabbits
• Tocopherols
• Ubiquinone (metabolism)
• Vitamin E (analogs & derivatives, metabolism, therapeutic use)
• Vitamin E Deficiency (complications, metabolism)
• alpha-Tocopherol (analogs & derivatives)