Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.

Abstract

Eboracin, a substituted trioxyindenopyrrole, inhibited the tonic component of convulsive seizures induced in mice by pentylenetetrazol, electroshock or auditory stimulation. Single doses decreased the incidence of tonic-clonic seizures (ED50=28-35 mg/kg); complete inhibition of tonus followed doses of 40-150 mg/kg. A dose of 75-150 mg/kg of eboracin prolonged the duration and increased the severity of the myoclonic component of seizures induced by pentylenetetrazol.

• Authors: G J Alexander, N Chatterjie, L M Kopeloff
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 36 Issue 1 Pg. 153-6 (Apr 1982) ISSN: 0034-5164 [Print] United States
• PMID: 7079581 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Indenes
• eboracin
• Phenytoin
• Pentylenetetrazole

Topics

• Acoustic Stimulation
• Animals
• Anticonvulsants (pharmacology)
• Electroshock
• Indenes (pharmacology)
• Male
• Mice
• Myoclonus (physiopathology)
• Pentylenetetrazole (antagonists & inhibitors)
• Phenytoin (pharmacology)
• Seizures (physiopathology)