Control of a human tumour (Ewing sarcoma) in mice by a single lethal dose of dimethyl-myleran and bone marrow.

Abstract

A Ewing sarcoma grown in immunosuppressed mice was eradicated with a single lethal dose of dimethylmyleran (DMM) followed by autologous or syngeneic bone marrow. Sarcomas treated 2 weeks after grafting in a phase of rapid proliferation disappeared and large sarcomas treated after 6 or 10 weeks were reduced to necrotic tissue. A human osteosarcoma also regressed distinctly after this therapy while a human colon carcinoma responded poorly. Sub-lethal DMM treatment induced complete remissions in only 62% of the mice. Tumours which display sensitivity in this model may be treated clinically with lethal doses of DMM and autologous marrow transplantations.

• Authors: G L Floersheim, J Torhorst
• Journal: International journal of cancer (Int J Cancer) Vol. 27 Issue 6 Pg. 743-8 (Jun 15 1981) ISSN: 0020-7136 [Print] United States
• PMID: 7026462 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• dimethylmyleran
• Busulfan

Topics

• Animals
• Bone Marrow Transplantation
• Busulfan (administration & dosage, analogs & derivatives)
• Dose-Response Relationship, Drug
• Humans
• Immunosuppression Therapy
• Male
• Mice
• Mice, Inbred C3H
• Mice, Nude
• Neoplasm Transplantation
• Sarcoma, Ewing (drug therapy, pathology, therapy)