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Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial.

Abstract
The antiepileptic properties of carbamazepine (Tegretol) and clonazepam (Rivotril) were compared in a double-blind randomized study comprising 36 patients with newly diagnosed, untreated psychomotor epilepsy (partial seizures with complex symptomatology). No significant differences were found between the two drugs during the 6 months of treatment. Measurements of concentrations in plasma confirmed that the patients exceeded the accepted lower limit for therapeutic range of the drugs.
AuthorsB Mikkelsen, P Berggreen, P Joensen, O Kristensen, O Køhler, B O Mikkelsen
JournalEpilepsia (Epilepsia) Vol. 22 Issue 4 Pg. 415-20 (Aug 1981) ISSN: 0013-9580 [Print] United States
PMID7021140 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Benzodiazepinones
  • Carbamazepine
  • Clonazepam
Topics
  • Adolescent
  • Adult
  • Aged
  • Benzodiazepinones (therapeutic use)
  • Carbamazepine (administration & dosage, therapeutic use)
  • Child
  • Clinical Trials as Topic
  • Clonazepam (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Epilepsy, Temporal Lobe (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Random Allocation

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