A double-blind study of the value of treatment with a single dose tinidazole of partners to females with trichomoniasis.

Abstract

Tinidazole 2 g single oral dose was given to 137 females with positive trichomonal cultures. On a random basis the same dose of tinidazole was given to half the sexual partners, and matching placebo to the other half. One to two weeks after treatment 5 females had positive cultures, indicating a primary cure rate of 96.4%. At an average of 2 months after treatment and 6 weeks after resuming sexual activity, 118 females were reexamined; 17 had a positive culture, giving an overall relapse rate of 14.4%. The relapse rate with tinidazole-treated partner was 5.1%, and with placebo-treated partner 23.7% (p equals 0.01). The definitive cure rate after a single dose of tinidazole 2 g was in females with treated partner 91.8% and with untreated partner 72.6%. It is concluded that a single dose of tinidazole is an effective treatment for females with trichomoniasis but to avoid relapse it is necessary to treat the sexual partner too.

• Authors: J Lyng, J Christensen
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 60 Issue 2 Pg. 199-201 ( 1981) ISSN: 0001-6349 [Print] United States
• PMID: 7018164 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Nitroimidazoles
• Tinidazole

Topics

• Adolescent
• Adult
• Clinical Trials as Topic
• Coitus
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nitroimidazoles (therapeutic use)
• Tinidazole (administration & dosage, therapeutic use)
• Trichomonas Vaginitis (drug therapy, transmission)