Abstract |
An overdose of CCNU (600 mg over a 15-d period) was unintentionally ingested by a patient with advanced Hodgkin's disease subjected to combination chemotherapy. A severe bone marrow depression occurred 3 weeks after the start of the CCNU treatment. The nadir of the platelet count was reached after 4 weeks and that of the granulocyte count after 5 weeks. At the nadir of the white blood cell count, colony-forming cells (CFU-C) were found in significantly reduced numbers in the bone marrow, and were not found at all in the peripheral blood; the amount of colony-stimulating activity (CSA) produced by peripheral blood cells was reduced. However, the cells producing CSA recovered earlier than the CFU-C, and the CSA peak value was reached about 1 week before the peak value for CFU-C in the bone marrow. Thus, in vivo CSA-producing cells appeared to be more resistant to CCNU than were CFU-C, and their recovery appeared to be a prerequisite for the recovery of CFU-C and myelopoietic cells.
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Authors | P Hörnsten, B Sundman-Engberg, G Gahrton, B Johansson |
Journal | Scandinavian journal of haematology
(Scand J Haematol)
Vol. 31
Issue 1
Pg. 9-14
(Jul 1983)
ISSN: 0036-553X [Print] Denmark |
PMID | 6867612
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Nitrosourea Compounds
- Lomustine
|
Topics |
- Animals
- Colony-Forming Units Assay
- Dogs
- Granulocytes
(drug effects)
- Hematopoietic Stem Cells
(drug effects)
- Hodgkin Disease
(drug therapy)
- Humans
- Leukocyte Count
- Lomustine
(poisoning)
- Male
- Middle Aged
- Monocytes
(drug effects)
- Nitrosourea Compounds
(poisoning)
- Platelet Count
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