Occupational asthma due to inhalation of chloramine-T. I. Clinical observations and inhalation-provocation studies.

Abstract

Respiratory symptoms developed in 5 patients who were exposed to chloramine-T, a potent disinfectant used in cleaning butcheries, kitchens, and operating theaters. Skin tests, performed in 4 patients, showed an immediate type of wheal and flare reaction followed by a late-type infiltrative reaction. In 3 patients, inhalation tests with chloramine-T were done. 1 patient showed asthmatic bronchial obstruction, immediately after inhalation, followed by a late-type asthmatic reaction after some hours. 2 patients only exhibited late-type reactions, 4-8 h after challenge. The late bronchial response lasted for several hours or even days and was accompanied by leukocytosis in all 3 patients and a slight fever in 1 patient. No evidence of alveolar involvement appeared. Pre-challenge inhalation of cromoglycate in 1 patient ameliorated the late response considerably.

• Authors: J H Dijkman, P H Vooren, J A Kramps
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 64 Issue 4 Pg. 422-7 ( 1981) ISSN: 0020-5915 [Print] Switzerland
• PMID: 6782023 (Publication Type: Journal Article)

Chemical References

• Chloramines
• Tosyl Compounds
• chloramine-T
• Cromolyn Sodium

Topics

• Administration, Intranasal
• Adult
• Asthma (diagnosis, drug therapy, etiology)
• Bronchial Provocation Tests
• Chloramines (adverse effects)
• Cromolyn Sodium (therapeutic use)
• Female
• Forced Expiratory Volume
• Humans
• Male
• Occupational Diseases (diagnosis, etiology)
• Radiography, Thoracic
• Respiratory Function Tests
• Skin Tests
• Time Factors
• Tosyl Compounds