In experiment on cockerels, the interaction of sulphadimidine with
nitrovin manifested itself in an effect on the distribution of sulphadimidine, and particularly on its bloodlevel; this depended, among other factors, on the age of the animals. At
nitrovin medication, the bloodlevels of sulphadimidine were higher, mainly soon after administration, and their drop was quicker than in untreated animals. This effect on the levels of sulphadimidine in the blood was pronounced in three-week-old chickens, whereas in older birds it was feeble or absent. Except the higher level 30 min. after application to.five-week-old chickens given feed with 120 g t-1 of
nitrovin, the differences were statistically insignificant. The changes in the concentration of sulphonamide in the liver and kidneys corresponded with the changes observed in the blood; the concentration in muscle was not affected by
nitrovin under the given conditions. The favourable effect of
nitrovin on
weight gains, demonstrated in principle during the experiment, was directly dependent upon the concentration of
nitrovin in feed. As to the effect of the length of its administratiion, the three-day administration of
nitrovin (before weighing) to cockerels up to five weeks of age had a better influence on gains than administration from the sixth day after the medicated of the chickens. In older cockerels the gains were better in the groups treated for a longer time, i. e. from the sixth day from hatching.