Abstract |
The nephrotoxic potential of S86451 (2'guanidyl, 2'deamino gentamicin C1) has been investigated in Sprague-Dawley rats at 10 and 25 mg/kg, in comparison with gentamicin at 4 and 10 mg/kg. The criteria were (i) the severity of the lysosomal phospholipidosis, as assessed by both biochemical and morphological investigations; (ii) the degree of tubular regeneration, a consequence of the aminoglycoside-induced focal necrosis measured by 3H-thymidine incorporation into kidney cortex DNA. S86451 was found at least 2-5 times less toxic than gentamicin. Thus, this compound should be a safer antibiotic than gentamicin in combating organisms with a similar sensitivity to either drug.
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Authors | P Maldague, G Laurent, M B Carlier, P Tulkens |
Journal | Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
(Arch Toxicol Suppl)
Vol. 7
Pg. 455-8
( 1984)
ISSN: 0171-9750 [Print] Germany |
PMID | 6596014
(Publication Type: Journal Article)
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Chemical References |
- Gentamicins
- 2'-guanidyl-2'-deaminogentamicin C1
- DNA
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Topics |
- Animals
- DNA
(biosynthesis)
- Gentamicins
(toxicity)
- Kidney
(drug effects, metabolism, pathology)
- Kidney Cortex
(metabolism, pathology)
- Kidney Tubules, Proximal
(metabolism, pathology)
- Lysosomes
(drug effects)
- Necrosis
- Rats
- Rats, Inbred Strains
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