Connective tissue activating peptide III. Induction of synthesis and secretion of plasminogen activator by synovial fibroblasts.

Abstract

Connective tissue activating peptide III (CTAP-III) is a platelet factor that induces, in cultured connective tissue cells, activities observed in chronic inflammation. In this study we measured plasminogen activator secretion by synovial fibroblasts after stimulation by CTAP-III. Increased plasminogen activator secretion was observed 24-48 hours after stimulation. Induction was prevented by dexamethasone (10(-9)-10(-7) M), cycloheximide (1 microgram/ml) and, variably, by actinomycin D (0.3 microgram/ml), but not by cytosine arabinoside (10(-4)M). This is the first evidence that CTAP-III induces degradative as well as proliferative activity by connective tissue cells.

• Authors: C G Ragsdale, C W Castor, D J Roberts, K H Swartz
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 27 Issue 6 Pg. 663-7 (Jun 1984) ISSN: 0004-3591 [Print] United States
• PMID: 6539601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Peptides
• Cytarabine
• Dactinomycin
• connective tissue-activating peptide
• Dexamethasone
• Cycloheximide
• Plasminogen Activators

Topics

• Cycloheximide (pharmacology)
• Cytarabine (pharmacology)
• Dactinomycin (pharmacology)
• Dexamethasone (pharmacology)
• Fibroblasts (drug effects, metabolism)
• Humans
• Peptides (physiology)
• Plasminogen Activators (biosynthesis, metabolism)
• Synovial Membrane (cytology)