Revised analysis of amino acid replacement in a prealbumin variant (SKO-III) associated with familial amyloidotic polyneuropathy of Jewish origin.

Abstract

Amyloid fibril protein (SKO-III) of 14K daltons associated with familial amyloidotic polyneuropathy of Jewish type was identified by Pras et al. as a prealbumin variant with a single amino acid substitution of a glycine for a threonine at position 49, mainly based on data obtained by automated sequence analyses. Structural re-investigation of SKO-III was performed by comparing tryptic peptide maps of SKO-III and normal human prealbumin. The present analysis reveals that the reported replacement at position 49 is not present in the molecule of SKO-III. SKO-III should be revised to be a prealbumin variant with one amino acid substitution of an isoleucine for a phenylalanine at position 33.

• Authors: M Nakazato, K Kangawa, N Minamino, S Tawara, H Matsuo, S Araki
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 123 Issue 3 Pg. 921-8 (Sep 28 1984) ISSN: 0006-291X [Print] United States
• PMID: 6487335 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Amyloid
• Peptide Fragments
• Prealbumin
• amyloid fibril protein SKO-III

Topics

• Amino Acid Sequence
• Amino Acids (analysis)
• Amyloid (genetics)
• Amyloidosis (genetics)
• Genetic Variation
• Humans
• Jews
• Nervous System Diseases (genetics)
• Peptide Fragments (analysis)
• Prealbumin (genetics)