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Selective response to the anticonvulsant carbamazepine in manic-depressive illness: a case study.

Abstract
Acute and prophylactic effects of carbamazepine are documented in a double-blind clinical trial in a 55-year-old treatment-refractory, lithium-non-responsive, manic-depressive patient. Double-blind crossover to two other anticonvulsants was also achieved; the patient showed no evidence of response to phenytoin or valproic acid. The clinical and theoretical issues raised by the selective response to carbamazepine in this patient are discussed.
AuthorsR M Post, W Berrettini, T W Uhde, C Kellner
JournalJournal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 4 Issue 4 Pg. 178-85 (Aug 1984) ISSN: 0271-0749 [Print] United States
PMID6432857 (Publication Type: Case Reports, Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Carbamazepine
  • Valproic Acid
  • Phenytoin
  • Lithium
Topics
  • Bipolar Disorder (drug therapy)
  • Carbamazepine (therapeutic use)
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Lithium (therapeutic use)
  • Middle Aged
  • Phenytoin (therapeutic use)
  • Valproic Acid (therapeutic use)

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