Abstract |
Acute and prophylactic effects of carbamazepine are documented in a double-blind clinical trial in a 55-year-old treatment-refractory, lithium-non-responsive, manic-depressive patient. Double-blind crossover to two other anticonvulsants was also achieved; the patient showed no evidence of response to phenytoin or valproic acid. The clinical and theoretical issues raised by the selective response to carbamazepine in this patient are discussed.
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Authors | R M Post, W Berrettini, T W Uhde, C Kellner |
Journal | Journal of clinical psychopharmacology
(J Clin Psychopharmacol)
Vol. 4
Issue 4
Pg. 178-85
(Aug 1984)
ISSN: 0271-0749 [Print] United States |
PMID | 6432857
(Publication Type: Case Reports, Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Carbamazepine
- Valproic Acid
- Phenytoin
- Lithium
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Topics |
- Bipolar Disorder
(drug therapy)
- Carbamazepine
(therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Humans
- Lithium
(therapeutic use)
- Middle Aged
- Phenytoin
(therapeutic use)
- Valproic Acid
(therapeutic use)
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