The pathology of the feline model of mucopolysaccharidosis I.

Abstract

Five cats with feline alpha-L-iduronidase-deficient mucopolysaccharidosis were studied. Membrane-bound cytoplasmic inclusions were present in central nervous system neurons, hepatocytes, chondrocytes, vascular and splenic smooth muscle cells, bone marrow leukocytes, and fibroblasts of the skin, eye, and cardiac valves. The lesions in these cats closely resemble those described in human patients with mucopolysaccharidosis I H (Hurler syndrome).

• Authors: M E Haskins, G D Aguirre, P F Jezyk, R J Desnick, D F Patterson
• Journal: The American journal of pathology (Am J Pathol) Vol. 112 Issue 1 Pg. 27-36 (Jul 1983) ISSN: 0002-9440 [Print] United States
• PMID: 6407329 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Animals
• Bone Marrow (pathology)
• Bone and Bones (pathology)
• Cardiovascular System (pathology)
• Cartilage (pathology)
• Cat Diseases (pathology)
• Cats
• Central Nervous System (pathology)
• Eye (pathology)
• Female
• Humans
• Liver (pathology)
• Male
• Mucopolysaccharidosis I (pathology, veterinary)
• Muscle, Smooth (pathology)
• Muscles (pathology)
• Pedigree
• Skin (pathology)
• Spleen (pathology)