[Effect of riodoxol on herpes simplex virus morphogenesis in experimental eye infection].

Abstract

The effect of riodoxol on herpes simplex type 1 viruses was studied. It was shown to affect multiplication and maturation of the virus as manifested in the appearance of virions with incomplete nucleoid structure and long-term presence of virions in cytoplasmic vacuoles in cells. Submicroscopic changes suggest a dual effect of riodoxol on herpes simplex virus: on the DNA replicative cycle and on the stage of late maturation of virus at the time of its release from the nucleus.'

• Authors: L F Stebaeva, I S Nikolaeva, G N Pershin
• Journal: Voprosy virusologii (Vopr Virusol) 1982 Jan-Feb Issue 1 Pg. 90-4 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Vliianie riodoksola na morfogenez virusa gerpesa prostogo pri éksperimetal'noĭ infektsii glaz.
• PMID: 6280397 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Resorcinols
• 2,4,6-triiodoresorcinol

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Drug Evaluation, Preclinical
• Eye (ultrastructure)
• Keratitis, Dendritic (drug therapy, microbiology)
• Microscopy, Electron
• Morphogenesis (drug effects)
• Rabbits
• Resorcinols (therapeutic use)
• Simplexvirus (drug effects, ultrastructure)