Abstract |
The effects of Benetazone Spofa ( trimethazone) in a dose of 1000 mg/day with those of phenylbutazone in a dose of 600 mg day in patients with rheumatoid arthritis were tested in a short-term double-blind trial (3 weeks) and in a long-term double-blind trial (12 weeks). The short-term trial failed to disclose a significant superior effect of phenylbutazone, and the continued prolonged therapy showed, on the contrary, the higher effectiveness of the new derivative, but the difference was not statistically significant. The main advantage of Benetazone consisted of its lower toxicity, better tolerance and of the much lower tendency to produce fluid retention compared to phenylbutazone.
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Authors | K Pavelka, O Vojtisek, A Bremová, D Kauková, D Hándlová |
Journal | International journal of clinical pharmacology and biopharmacy
(Int J Clin Pharmacol Biopharm)
Vol. 14
Issue 1
Pg. 20-8
(Jul 1976)
ISSN: 0340-0026 [Print] Germany |
PMID | 61951
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Arthritis, Rheumatoid
(drug therapy)
- Clinical Trials as Topic
- Humans
- Kinetics
- Palliative Care
- Phenylbutazone
(analogs & derivatives, blood, therapeutic use)
- Pyrazoles
(therapeutic use)
- Time Factors
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