A model was experimentally made with 2 hours serial infusion of
thromboplastin (Tp) into rabbits to examine the
drug's effect on a hemorrhagic tendency and to elucidate the coagulation and fibrinolytic system in acute
DIC encountered in obstetrics, and the system was periodically observed. Groups given the
drug, given it during pregnancy, those which bled massively, and those with accelerated fibrinolysis were prepared. The results are as follows. 1)
Fibrinogen, PT, APTT, TEG, ELT, AT-III,
antiplasmin activity, and platelet count varied markedly from the initiation of Tp injection, and returned to normal following termination. 2) Blood from the
heparin dose group showed non-coagulation but decreases in the platelet count and
fibrinogen were inhibited. 3) In the
aprotinin dose group, serial 2 hour administration induced inhibition of fibrinolysis despite the relatively delayed appearance of anti-fibrinolytic activity. 4) No fibrinolytic effects were seen in anti-
plasmin activity or ELT in the
tranexamic acid dose group. 5) Lowering of parameters examined was marked in the Tp dose group during pregnancy. 6) The mortality rate up to 6 hours after Tp infusion was 54.5% with solely given, and 10% with group given
drug. 7) Death within one hour of Tp infusion in the mass
bleeding group, being rated for 50%, was improved to 16.7% by the pre-administration of
urokinase.