Beta-adrenoreceptor mechanisms in essential tremor: a comparative single dose study of the effect of a non-selective and a beta-2 selective adrenoreceptor antagonist.

Abstract

In order to study the mode of action of beta-adrenoreceptor antagonists in essential tremor the efficacy of single oral doses of 2, 4 and 10 mg LI 32-468, a peripherally acting, selective beta-2 adrenoreceptor antagonist, was compared with a single oral dose of 120 mg propranolol in a randomised, double blind, placebo controlled trial. Both the lowest dose of LI and propranolol were shown to be equally superior to placebo in attenuating tremor magnitude. This finding supports the contention that the beneficial effect of beta-adrenoreceptor antagonists in essential tremor is mediated via peripheral beta-2 receptor mechanisms.

• Authors: L Cleeves, L J Findley
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 47 Issue 9 Pg. 976-82 (Sep 1984) ISSN: 0022-3050 [Print] England
• PMID: 6148382 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic beta-Antagonists
• Propanolamines
• Receptors, Adrenergic, beta
• LI 32-468
• Propranolol

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Adult
• Aged
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Propanolamines (therapeutic use)
• Propranolol (therapeutic use)
• Receptors, Adrenergic, beta (drug effects)
• Tremor (drug therapy)